Virus or malware infection?

I've used Spybot, Malwarebytes, and other security softwares, still getting popups It's not even show up when I run these programs. What else can I do? Ocassionally a new tab opens to some advertising site, also in the bottom corner of each browser, a bout of pop-ups appear, like "Speed up repair PC and random ads on the other corner".

You have used all the security softwares as they are malware softwares, My suggestion is just uninstall all the security softwares and once go through repair windows by inserting xp bootable CD or which ever OS you are using. Just disconnect from the internet before reparing OS. After repairing go to control panel uninstall the unknown or unused or unnecessary programmes and restart your computer, reset the browsers settings to default. Once reset completed connect your system to the Internet, just download the Norton Internet security trial version or if you can afford buy one. After installing update virus definitions. Disconnect your computer from internet and scan your whole computer, it compulsory detects threats clean them and restart your computer. That's it your system is clean.

Norton Internet Security provides excellent protection by these type of malwares, trojans, viruses...etc. Some programmes are automatically installed by few websites like adware softwares, malwares or toolbars...etc.

Better aware of all these things before browsing an unknown site or a malware site. Have a good browsers like Internet Explorer, Google Chrome, Mozilla Firefox. Allow them to Auto update browsers beacuse every update has bug fixes, add on features...etc